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Cortical, juxtacortical lesions, and U-fiber lesions. Arrows: multiple small juxtacortical and cortical lesions throughout cerebral hemispheres. By definition, no white matter may interpose between a juxtacortical lesion and the cortex. Note U-fiber lesions along arcuate fibers in middle left frontal lobe, highly characteristic of demyelination and not seen in normal aging or vascular disease.
